Dr Kamar Ameen-Ali - Is it time to look at alternatives to rodent models for dementia breakthroughs?

Dr Kamar Ameen-Ali narrates her blog written for Dementia Researcher.

Modelling human disease in animals has significantly advanced our understanding of major diseases and ways of treating them. Mammalian model systems, like mice, continue to be the dominant model of choice, with 79% of experimental and breeding procedures using rats or mice in Great Britain in 2020. However, these traditional models can be bottlenecks in the research pipeline, delaying progress in areas where effective therapeutics are desperately needed. In a previous blog, Kamar questioned whether a reliance on animal models, specifically mice, had delayed progress in dementia research. Now she looks at the alternatives and consider whether they can drive forward the breakthroughs we need in dementia research.

Find the original text, and narration here on our website.

https://www.dementiaresearcher.nihr.ac.uk/guest-blog-is-it-time-to-look-at-alternatives-to-rodent-models-for-dementia-breakthroughs/

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Dr Kamar Ameen-Ali is a Lecturer in Biomedical Science at Teesside University & Affiliate Researcher at Glasgow University. In addition to teaching, Kamar is exploring how neuroinflammation following traumatic brain injury contributes to the progression of neurodegenerative diseases that lead to dementia. Having first pursued a career as an NHS Psychologist, Kamar went back to University in Durham to look at rodent behavioural tasks to completed her PhD, and then worked as a regional Programme Manager for NC3Rs.

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